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-Structure paper
Title | Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain A beta Reduction in Rodents. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 7, Page 271-276, Year 2016 |
Publish date | Nov 9, 2015 (structure data deposition date) |
Authors | Wu, Y.J. / Guernon, J. / Yang, F. / Snyder, L. / Shi, J. / Mcclure, A. / Rajamani, R. / Park, H. / Ng, A. / Lewis, H. ...Wu, Y.J. / Guernon, J. / Yang, F. / Snyder, L. / Shi, J. / Mcclure, A. / Rajamani, R. / Park, H. / Ng, A. / Lewis, H. / Chang, C. / Camac, D. / Toyn, J.H. / Ahlijanian, M.K. / Albright, C.F. / Macor, J.E. / Thompson, L.A. |
External links | Acs Med. Chem. Lett. / PubMed:26985314 |
Methods | X-ray diffraction |
Resolution | 1.98 - 2.11 Å |
Structure data | PDB-5enk: PDB-5enm: |
Chemicals | ChemComp-GOL: ChemComp-IOD: ChemComp-5QV: ChemComp-HOH: ChemComp-5QU: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / BACE / Hydrolase-Hydrolase Inhibitor complex |