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-Structure paper
Title | Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. |
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Journal, issue, pages | Chemmedchem, Vol. 10, Page 1884-1891, Year 2015 |
Publish date | Aug 28, 2015 (structure data deposition date) |
Authors | Marzinzik, A.L. / Amstutz, R. / Bold, G. / Bourgier, E. / Cotesta, S. / Glickman, J.F. / Gotte, M. / Henry, C. / Lehmann, S. / Hartwieg, J.C. ...Marzinzik, A.L. / Amstutz, R. / Bold, G. / Bourgier, E. / Cotesta, S. / Glickman, J.F. / Gotte, M. / Henry, C. / Lehmann, S. / Hartwieg, J.C. / Ofner, S. / Pelle, X. / Roddy, T.P. / Rondeau, J.M. / Stauffer, F. / Stout, S.J. / Widmer, A. / Zimmermann, J. / Zoller, T. / Jahnke, W. |
External links | Chemmedchem / PubMed:26381451 |
Methods | X-ray diffraction |
Resolution | 2.08 - 2.4 Å |
Structure data | PDB-5dgn: PDB-5diq: PDB-5djp: PDB-5djr: PDB-5djv: |
Chemicals | ChemComp-59Y: ChemComp-HOH: ChemComp-GOL: ChemComp-5B9: ChemComp-MG: ChemComp-PO4: ChemComp-5BJ: ChemComp-5BK: ChemComp-5BL: |
Source |
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Keywords | TRANSFERASE / ISOPRENE BIOSYNTHESIS; CHOLESTEROL BIOSYNTHESIS / ISOPRENE BIOSYNTHESIS / CHOLESTEROL BIOSYNTHESIS |