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TitleHepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page E2862-E2871, Year 2017
Publish dateOct 23, 2016 (structure data deposition date)
AuthorsPyzik, M. / Rath, T. / Kuo, T.T. / Win, S. / Baker, K. / Hubbard, J.J. / Grenha, R. / Gandhi, A. / Kramer, T.D. / Mezo, A.R. ...Pyzik, M. / Rath, T. / Kuo, T.T. / Win, S. / Baker, K. / Hubbard, J.J. / Grenha, R. / Gandhi, A. / Kramer, T.D. / Mezo, A.R. / Taylor, Z.S. / McDonnell, K. / Nienaber, V. / Andersen, J.T. / Mizoguchi, A. / Blumberg, L. / Purohit, S. / Jones, S.D. / Christianson, G. / Lencer, W.I. / Sandlie, I. / Kaplowitz, N. / Roopenian, D.C. / Blumberg, R.S.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:28330995
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-5bjt:
Crystal structure of human FcRn with a peptide inhibitor at multiple sites
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM/INHIBITOR / immunoglobulin binding protein / cell membrane / disulfide bond / glycoprotein / IgG-binding protein / immunoglobulin domain / receptor / transmembrane / amyloid / amyloidosis / disease mutation / glycation / immune response / MHC I / pyrrolidone carboxylic acid / secreted / IMMUNE SYSTEM-INHIBITOR complex

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