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-Structure paper
Title | Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency. |
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Journal, issue, pages | Sci Rep, Vol. 5, Page 12222-12222, Year 2015 |
Publish date | Feb 9, 2015 (structure data deposition date) |
Authors | Zheng, W.L. / Qiu, L. / Wang, R. / Feng, X.H. / Han, Y.P. / Zhu, Y.L. / Chen, D.Z. / Liu, Y.J. / Jin, L.H. / Li, Y. |
External links | Sci Rep / PubMed:26183621 |
Methods | X-ray diffraction |
Resolution | 1.98 Å |
Structure data | PDB-4y29: |
Chemicals | ChemComp-CTI: ChemComp-HOH: |
Source |
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Keywords | DNA BINDING PROTEIN/TRANSCRIPTION / AF-2 helix / ligand binding pocket / three-layer helical sandwich / transcription regulator PPARg / NR1C3 / Peroxisome proliferator-activated receptor gamma / NHR / nuclear receptor / coactivator / Transcription factor / DNA BINDING PROTEIN-TRANSCRIPTION complex |