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| Title | Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious beta-secretase inhibitors for the potential treatment of Alzheimer's disease. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 25, Page 767-774, Year 2015 |
| Publish date | Jan 12, 2015 (structure data deposition date) |
 Authors | Chen, J.J. / Liu, Q. / Yuan, C. / Gore, V. / Lopez, P. / Ma, V. / Amegadzie, A. / Qian, W. / Judd, T.C. / Minatti, A.E. ...Chen, J.J. / Liu, Q. / Yuan, C. / Gore, V. / Lopez, P. / Ma, V. / Amegadzie, A. / Qian, W. / Judd, T.C. / Minatti, A.E. / Brown, J. / Cheng, Y. / Xue, M. / Zhong, W. / Dineen, T.A. / Epstein, O. / Human, J. / Kreiman, C. / Marx, I. / Weiss, M.M. / Hitchcock, S.A. / Powers, T.S. / Chen, K. / Wen, P.H. / Whittington, D.A. / Cheng, A.C. / Bartberger, M.D. / Hickman, D. / Werner, J.A. / Vargas, H.M. / Everds, N.E. / Vonderfecht, S.L. / Dunn, R.T. / Wood, S. / Fremeau, R.T. / White, R.D. / Patel, V.F. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:25613679 |
| Methods | X-ray diffraction |
| Resolution | 1.8 Å |
| Structure data |  PDB-4xkx: |
| Chemicals |  ChemComp-IOD:  ChemComp-43K:  ChemComp-GOL:  ChemComp-HOH: |
| Source |
|
 Keywords | Hydrolase/hydrolase inhibitor / aspartic protease / Hydrolase-hydrolase inhibitor complex |
homo sapiens (human)