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-Structure paper
Title | Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus. |
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Journal, issue, pages | Proc Natl Acad Sci U S A, Vol. 112, Issue 43, Page E5805-E5814, Year 2015 |
Publish date | Oct 27, 2015 |
Authors | Zohar Eyal / Donna Matzov / Miri Krupkin / Itai Wekselman / Susanne Paukner / Ella Zimmerman / Haim Rozenberg / Anat Bashan / Ada Yonath / |
PubMed Abstract | The emergence of bacterial multidrug resistance to antibiotics threatens to cause regression to the preantibiotic era. Here we present the crystal structure of the large ribosomal subunit from ...The emergence of bacterial multidrug resistance to antibiotics threatens to cause regression to the preantibiotic era. Here we present the crystal structure of the large ribosomal subunit from Staphylococcus aureus, a versatile Gram-positive aggressive pathogen, and its complexes with the known antibiotics linezolid and telithromycin, as well as with a new, highly potent pleuromutilin derivative, BC-3205. These crystal structures shed light on specific structural motifs of the S. aureus ribosome and the binding modes of the aforementioned antibiotics. Moreover, by analyzing the ribosome structure and comparing it with those of nonpathogenic bacterial models, we identified some unique internal and peripheral structural motifs that may be potential candidates for improving known antibiotics and for use in the design of selective antibiotic drugs against S. aureus. |
External links | Proc Natl Acad Sci U S A / PubMed:26464510 / PubMed Central |
Methods | X-ray diffraction |
Resolution | 3.392 - 3.526 Å |
Structure data | PDB-4wce: PDB-4wf9: PDB-4wfa: PDB-4wfb: |
Chemicals | ChemComp-MPD: ChemComp-MN: ChemComp-MG: ChemComp-EPE: ChemComp-SPD: ChemComp-EOH: ChemComp-TEL: ChemComp-ZLD: ChemComp-NA: ChemComp-3LK: |
Source |
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Keywords | RIBOSOME / RNA / bacteria |