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Title | Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 22, Page 6570-6585, Year 2014 |
Publish date | Jun 8, 2014 (structure data deposition date) |
Authors | Rzasa, R.M. / Frohn, M.J. / Andrews, K.L. / Chmait, S. / Chen, N. / Clarine, J.G. / Davis, C. / Eastwood, H.A. / Horne, D.B. / Hu, E. ...Rzasa, R.M. / Frohn, M.J. / Andrews, K.L. / Chmait, S. / Chen, N. / Clarine, J.G. / Davis, C. / Eastwood, H.A. / Horne, D.B. / Hu, E. / Jones, A.D. / Kaller, M.R. / Kunz, R.K. / Miller, S. / Monenschein, H. / Nguyen, T. / Pickrell, A.J. / Porter, A. / Reichelt, A. / Zhao, X. / Treanor, J.J. / Allen, J.R. |
External links | Bioorg. Med. Chem. / PubMed:25456383 |
Methods | X-ray diffraction |
Resolution | 2.65 - 2.77 Å |
Structure data | PDB-4tpm: PDB-4tpp: |
Chemicals | ChemComp-SO4: ChemComp-GOL: ChemComp-35E: ChemComp-ZN: ChemComp-HOH: ChemComp-35D: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / PDE10A / quinolines / Hydrolase-Hydrolase Inhibitor complex / Phosphodiesterase 10A |