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-Structure paper
Title | Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. |
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Journal, issue, pages | Science, Vol. 346, Page 638-641, Year 2014 |
Publish date | May 19, 2014 (structure data deposition date) |
Authors | Baud, M.G. / Lin-Shiao, E. / Cardote, T. / Tallant, C. / Pschibul, A. / Chan, K.H. / Zengerle, M. / Garcia, J.R. / Kwan, T.T. / Ferguson, F.M. / Ciulli, A. |
External links | Science / PubMed:25323695 |
Methods | X-ray diffraction |
Resolution | 1.5 - 1.8 Å |
Structure data | PDB-4qeu: PDB-4qev: PDB-4qew: |
Chemicals | ChemComp-ACT: ChemComp-GOL: ChemComp-HOH: ChemComp-31O: ChemComp-2PE: ChemComp-NI: ChemComp-31P: |
Source |
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Keywords | TRANSCRIPTION / Bromodomain-containing protein 2 / KIAA9001 / RING3 / Transcription regulation / transcription/transcription inhibitor / transcription-transcription inhibitor complex |