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-Structure paper
Title | Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 111, Page 8013-8018, Year 2014 |
Publish date | Dec 20, 2013 (structure data deposition date) |
Authors | Preiswerk, N. / Beck, T. / Schulz, J.D. / Milovnik, P. / Mayer, C. / Siegel, J.B. / Baker, D. / Hilvert, D. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:24847076 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.9 Å |
Structure data | PDB-4o5s: PDB-4o5t: |
Chemicals | ChemComp-HOH: ChemComp-XDA: |
Source |
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Keywords | De Novo Protein / Hydrolase / protein engineering / computer-aided design / Diels-Alder reaction / enzyme design / directed evolution / substrate specificity / beta-propeller / helix-loop-helix / artificial catalyst / Diels-Alderase / catalyst for cycloaddition / enzyme-product analog complex' |