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-Structure paper
Title | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 325-338, Year 2014 |
Publish date | Sep 16, 2013 (structure data deposition date) |
Authors | St Jean, D.J. / Ashton, K.S. / Bartberger, M.D. / Chen, J. / Chmait, S. / Cupples, R. / Galbreath, E. / Helmering, J. / Hong, F.T. / Jordan, S.R. ...St Jean, D.J. / Ashton, K.S. / Bartberger, M.D. / Chen, J. / Chmait, S. / Cupples, R. / Galbreath, E. / Helmering, J. / Hong, F.T. / Jordan, S.R. / Liu, L. / Kunz, R.K. / Michelsen, K. / Nishimura, N. / Pennington, L.D. / Poon, S.F. / Reid, D. / Sivits, G. / Stec, M.M. / Tadesse, S. / Tamayo, N. / Van, G. / Yang, K.C. / Zhang, J. / Norman, M.H. / Fotsch, C. / Lloyd, D.J. / Hale, C. |
External links | J. Med. Chem. / PubMed:24405213 |
Methods | X-ray diffraction |
Resolution | 2.2 - 2.22 Å |
Structure data | PDB-4mqu: PDB-4mro: |
Chemicals | ChemComp-MG9: ChemComp-S6P: ChemComp-IOD: ChemComp-GOL: ChemComp-SO4: ChemComp-HOH: ChemComp-MG0: |
Source |
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Keywords | Transferase Inhibitor / SIS domains / Regulatory protein / Binds fructose phosphates and glucokinase / Glucokinase / phospho-fructose |