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-Structure paper
Title | GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions. |
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Journal, issue, pages | J. Virol., Vol. 88, Page 3586-3590, Year 2014 |
Publish date | Aug 14, 2013 (structure data deposition date) |
Authors | Grantz Saskova, K. / Kozisek, M. / Stray, K. / de Jong, D. / Rezaova, P. / Brynda, J. / van Maarseveen, N.M. / Nijhuis, M. / Cihlar, T. / Konvalinka, J. |
External links | J. Virol. / PubMed:24371077 |
Methods | X-ray diffraction |
Resolution | 2.05 - 2.22 Å |
Structure data | PDB-4m8x: PDB-4m8y: |
Chemicals | ChemComp-KGQ: ChemComp-HOH: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / HIV protease / aspartic protease / GS8374 / Hydrolase-Hydrolase Inhibitor complex / HIV-1 protease / amino acid insertion |