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-Structure paper
Title | Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 4, Page 835-840, Year 2013 |
Publish date | Jul 19, 2013 (structure data deposition date) |
Authors | Gehling, V.S. / Hewitt, M.C. / Vaswani, R.G. / Leblanc, Y. / Cote, A. / Nasveschuk, C.G. / Taylor, A.M. / Harmange, J.C. / Audia, J.E. / Pardo, E. ...Gehling, V.S. / Hewitt, M.C. / Vaswani, R.G. / Leblanc, Y. / Cote, A. / Nasveschuk, C.G. / Taylor, A.M. / Harmange, J.C. / Audia, J.E. / Pardo, E. / Joshi, S. / Sandy, P. / Mertz, J.A. / Sims, R.J. / Bergeron, L. / Bryant, B.M. / Bellon, S. / Poy, F. / Jayaram, H. / Sankaranarayanan, R. / Yellapantula, S. / Bangalore Srinivasamurthy, N. / Birudukota, S. / Albrecht, B.K. |
External links | ACS Med Chem Lett / PubMed:24900758 |
Methods | X-ray diffraction |
Resolution | 1.29 - 2.21 Å |
Structure data | PDB-4lr6: PDB-4lrg: |
Chemicals | ChemComp-FMT: ChemComp-1XA: ChemComp-HOH: ChemComp-1XB: |
Source |
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Keywords | TRANSCRIPTION REGULATOR/INHIBITOR / BET inhibitor / Brd4 first bromodomain / TRANSCRIPTION REGULATOR-INHIBITOR complex |