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-Structure paper
Title | Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 5764-5776, Year 2014 |
Publish date | Jul 16, 2013 (structure data deposition date) |
![]() | De Schutter, J.W. / Park, J. / Leung, C.Y. / Gormley, P. / Lin, Y.S. / Hu, Z. / Berghuis, A.M. / Poirier, J. / Tsantrizos, Y.S. |
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Methods | X-ray diffraction |
Resolution | 2.3 - 2.35 Å |
Structure data | ![]() PDB-4lpg: ![]() PDB-4lph: |
Chemicals | ![]() ChemComp-PO4: ![]() ChemComp-1MV: ![]() ChemComp-HOH: ![]() ChemComp-YL3: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |