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Title | Identification of NVP-TNKS656: The Use of Structure-Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 6495-6511, Year 2013 |
Publish date | Jul 2, 2013 (structure data deposition date) |
Authors | Shultz, M.D. / Cheung, A.K. / Kirby, C.A. / Firestone, B. / Fan, J. / Chen, C.H. / Chen, Z. / Chin, D.N. / Dipietro, L. / Fazal, A. ...Shultz, M.D. / Cheung, A.K. / Kirby, C.A. / Firestone, B. / Fan, J. / Chen, C.H. / Chen, Z. / Chin, D.N. / Dipietro, L. / Fazal, A. / Feng, Y. / Fortin, P.D. / Gould, T. / Lagu, B. / Lei, H. / Lenoir, F. / Majumdar, D. / Ochala, E. / Palermo, M.G. / Pham, L. / Pu, M. / Smith, T. / Stams, T. / Tomlinson, R.C. / Toure, B.B. / Visser, M. / Wang, R.M. / Waters, N.J. / Shao, W. |
External links | J. Med. Chem. / PubMed:23844574 |
Methods | X-ray diffraction |
Resolution | 2.05 - 2.521 Å |
Structure data | PDB-4li6: PDB-4li7: PDB-4li8: |
Chemicals | ChemComp-ZN: ChemComp-SO4: ChemComp-1XO: ChemComp-HOH: ChemComp-NA: ChemComp-1XP: ChemComp-1XQ: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |