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-Structure paper
Title | Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 7788-7803, Year 2013 |
Publish date | May 3, 2013 (structure data deposition date) |
Authors | Kester, R.F. / Donnell, A.F. / Lou, Y. / Remiszewski, S.W. / Lombardo, L.J. / Chen, S. / Le, N.T. / Lo, J. / Moliterni, J.A. / Han, X. ...Kester, R.F. / Donnell, A.F. / Lou, Y. / Remiszewski, S.W. / Lombardo, L.J. / Chen, S. / Le, N.T. / Lo, J. / Moliterni, J.A. / Han, X. / Hogg, J.H. / Liang, W. / Michoud, C. / Rupert, K.C. / Mischke, S. / Le, K. / Weisel, M. / Janson, C.A. / Lukacs, C.M. / Fretland, A.J. / Hong, K. / Polonskaia, A. / Gao, L. / Li, S. / Solis, D.S. / Aguilar, D. / Tardell, C. / Dvorozniak, M. / Tannu, S. / Lee, E.C. / Schutt, A.D. / Goggin, B. |
External links | J. Med. Chem. / PubMed:24093940 |
Methods | X-ray diffraction |
Resolution | 1.6 - 1.7 Å |
Structure data | PDB-4kju: PDB-4kjv: |
Chemicals | ChemComp-ZN: ChemComp-1RH: ChemComp-HOH: ChemComp-1RK: |
Source |
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Keywords | APOPTOSIS/APOPTOSIS INHIBITOR / XIAP inhibitors / BIR2 / benzodiazepinone / oncology / caspase / APOPTOSIS-APOPTOSIS INHIBITOR complex / benzoxazepinone |