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-Structure paper
Title | Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 3217-3227, Year 2013 |
Publish date | Jan 31, 2013 (structure data deposition date) |
Authors | Hewings, D.S. / Fedorov, O. / Filippakopoulos, P. / Martin, S. / Picaud, S. / Tumber, A. / Wells, C. / Olcina, M.M. / Freeman, K. / Gill, A. ...Hewings, D.S. / Fedorov, O. / Filippakopoulos, P. / Martin, S. / Picaud, S. / Tumber, A. / Wells, C. / Olcina, M.M. / Freeman, K. / Gill, A. / Ritchie, A.J. / Sheppard, D.W. / Russell, A.J. / Hammond, E.M. / Knapp, S. / Brennan, P.E. / Conway, S.J. |
External links | J. Med. Chem. / PubMed:23517011 |
Methods | X-ray diffraction |
Resolution | 1.72 - 1.84 Å |
Structure data | PDB-4j0r: PDB-4j0s: |
Chemicals | ChemComp-EDO: ChemComp-1H2: ChemComp-IOD: ChemComp-HOH: ChemComp-1H3: |
Source |
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Keywords | SIGNALING PROTEIN / BRD4 / Bromodomain containing protein 4 / CAP / HUNK1 / MCAP / Mitotic chromosome associated protein / Isoxazole / Structural Genomics Consortium / SGC |