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Title | Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-d]pyrimidine Analogues As Antifolates; Application of Buchwald-Hartwig Aminations of Heterocycles. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 4422-4441, Year 2013 |
Publish date | Jan 25, 2013 (structure data deposition date) |
Authors | Gangjee, A. / Namjoshi, O.A. / Raghavan, S. / Queener, S.F. / Kisliuk, R.L. / Cody, V. |
External links | J. Med. Chem. / PubMed:23627352 |
Methods | X-ray diffraction |
Resolution | 1.54 - 1.7 Å |
Structure data | PDB-4ixe: PDB-4ixf: PDB-4ixg: |
Chemicals | ChemComp-IXE: ChemComp-NDP: ChemComp-HOH: ChemComp-IXF: ChemComp-IXG: |
Source |
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Keywords | OXIDOREDUCTASE/Inhibitor / dihydrofolate reductase inhibitor cofactor ternary complex / reductase / OXIDOREDUCTASE-Inhibitor complex / pcDHFR-269-NADPH F69N ternary complex / dihydrofolate reductase inhibitor ternary complex double variant |