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-Structure paper
Title | Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 1023-1040, Year 2013 |
Publish date | Dec 4, 2012 (structure data deposition date) |
Authors | Kohlmann, A. / Zech, S.G. / Li, F. / Zhou, T. / Squillace, R.M. / Commodore, L. / Greenfield, M.T. / Lu, X. / Miller, D.P. / Huang, W.S. ...Kohlmann, A. / Zech, S.G. / Li, F. / Zhou, T. / Squillace, R.M. / Commodore, L. / Greenfield, M.T. / Lu, X. / Miller, D.P. / Huang, W.S. / Qi, J. / Thomas, R.M. / Wang, Y. / Zhang, S. / Dodd, R. / Liu, S. / Xu, R. / Xu, Y. / Miret, J.J. / Rivera, V. / Clackson, T. / Shakespeare, W.C. / Zhu, X. / Dalgarno, D.C. |
External links | J. Med. Chem. / PubMed:23302067 |
Methods | X-ray diffraction |
Resolution | 2.17 - 2.5 Å |
Structure data | PDB-4i8x: PDB-4i9h: PDB-4i9n: PDB-4i9u: |
Chemicals | ChemComp-6P3: ChemComp-HOH: ChemComp-1E4: ChemComp-1E6: ChemComp-1E5: ChemComp-1E7: |
Source |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / fragment / inhibitor / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / cancer |