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-Structure paper
Title | Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 1074-1083, Year 2013 |
Publish date | Oct 2, 2012 (structure data deposition date) |
Authors | Zhang, H. / Wang, Y.F. / Shen, C.H. / Agniswamy, J. / Rao, K.V. / Xu, C.X. / Ghosh, A.K. / Harrison, R.W. / Weber, I.T. |
External links | J. Med. Chem. / PubMed:23298236 |
Methods | X-ray diffraction |
Resolution | 1.06 - 1.49 Å |
Structure data | PDB-4hdb: PDB-4hdf: PDB-4hdp: PDB-4he9: PDB-4heg: |
Chemicals | ChemComp-G52: ChemComp-NA: ChemComp-CL: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/Hydrolase Inhibitor / aspartic acid protease / drug resistance / HIV-1 protease inhibitor GRL-0519 / HYDROLASE-Hydrolase Inhibitor complex |