+Search query
-Structure paper
Title | Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 55, Page 10047-10063, Year 2012 |
Publish date | Oct 1, 2012 (structure data deposition date) |
Authors | Zapf, C.W. / Gerstenberger, B.S. / Xing, L. / Limburg, D.C. / Anderson, D.R. / Caspers, N. / Han, S. / Aulabaugh, A. / Kurumbail, R. / Shakya, S. ...Zapf, C.W. / Gerstenberger, B.S. / Xing, L. / Limburg, D.C. / Anderson, D.R. / Caspers, N. / Han, S. / Aulabaugh, A. / Kurumbail, R. / Shakya, S. / Li, X. / Spaulding, V. / Czerwinski, R.M. / Seth, N. / Medley, Q.G. |
External links | J. Med. Chem. / PubMed:23098091 |
Methods | X-ray diffraction |
Resolution | 1.43 - 1.48 Å |
Structure data | PDB-4hct: PDB-4hcu: PDB-4hcv: |
Chemicals | ChemComp-18R: ChemComp-HOH: ChemComp-13L: ChemComp-13J: |
Source |
|
Keywords | transferase/transferase inhibitor / Kinase / transferase-transferase inhibitor complex |