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-Structure paper
Title | Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 4594-4604, Year 2012 |
Publish date | Dec 7, 2011 (structure data deposition date) |
Authors | Heald, R.A. / Jackson, P. / Savy, P. / Jones, M. / Gancia, E. / Burton, B. / Newman, R. / Boggs, J. / Chan, E. / Chan, J. ...Heald, R.A. / Jackson, P. / Savy, P. / Jones, M. / Gancia, E. / Burton, B. / Newman, R. / Boggs, J. / Chan, E. / Chan, J. / Choo, E. / Merchant, M. / Rudewicz, P. / Ultsch, M. / Wiesmann, C. / Yue, Q. / Belvin, M. / Price, S. |
External links | J. Med. Chem. / PubMed:22506516 |
Methods | X-ray diffraction |
Resolution | 2.7 - 2.705 Å |
Structure data | PDB-3v01: PDB-3v04: |
Chemicals | ChemComp-3V0: ChemComp-ATP: ChemComp-MG: ChemComp-V04: |
Source |
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Keywords | Transferase/Inhibitor / Kinase / Transferase-Inhibitor complex |