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TitleThe Identification of 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine (NVP-BKM120) as a Potent, Selective and Orally Bioavailable Class I PI3 Kinase Inhibitor for the Treatment of Cancer
Journal, issue, pagesTo be Published
Publish dateAug 24, 2011 (structure data deposition date)
AuthorsBurger, M.T. / Pecchi, S. / Wagman, A. / Ni, Z.-J. / Knapp, M.S. / Hendrickson, T. / Atallah, G. / Pfister, K. / Yanchen, Z. / Bartulis, S. ...Burger, M.T. / Pecchi, S. / Wagman, A. / Ni, Z.-J. / Knapp, M.S. / Hendrickson, T. / Atallah, G. / Pfister, K. / Yanchen, Z. / Bartulis, S. / Frazier, K. / Ng, S. / Smith, A. / Verhagen, J. / Haznedar, J. / Huh, K. / Iwanowicz, E. / Xin, X. / Menezes, D. / Merritt, H. / Lee, I. / Weisman, M. / Kaufman, S. / Crawford, K. / Chin, M. / Bussiere, D. / Shoemaker, K. / Zaror, I. / Maira, M. / Voliva, C.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-3tjp:
Crystal Structure of PI3K gamma with N6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-13K:
N~6~-(3,4-dimethoxyphenyl)-2-(morpholin-4-yl)-4,5'-bipyrimidine-2',6-diamine

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Multi-Domain / Lipid Kinase cell signaling / TRANSFERASE-TRANSFERASE INHIBITOR complex

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