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-Structure paper
Title | A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. |
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Journal, issue, pages | J. Biol. Chem., Vol. 286, Page 20677-20687, Year 2011 |
Publish date | Apr 12, 2011 (structure data deposition date) |
![]() | Eathiraj, S. / Palma, R. / Hirschi, M. / Volckova, E. / Nakuci, E. / Castro, J. / Chen, C.R. / Chan, T.C. / France, D.S. / Ashwell, M.A. |
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Methods | X-ray diffraction |
Resolution | 2.01 - 2.1 Å |
Structure data | ![]() PDB-3rhx: ![]() PDB-3ri1: |
Chemicals | ![]() ChemComp-3RH: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / FGFR1 kinase / FGFR2 kinase / inactive conformation / kinase-inhibitor complex / TRANSFERASE-TRANSFERASE INHIBITOR complex |