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Structure paper

TitleStructural basis of recognition of pathogen-associated molecular patterns and inhibition of proinflammatory cytokines by camel peptidoglycan recognition protein
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 16208-16217, Year 2011
Publish dateJul 27, 2010 (structure data deposition date)
AuthorsSharma, P. / Dube, D. / Singh, A. / Mishra, B. / Singh, N. / Sinha, M. / Dey, S. / Kaur, P. / Mitra, D.K. / Sharma, S. / Singh, T.P.
External linksJ. Biol. Chem. / PubMed:21454594
MethodsX-ray diffraction
Resolution1.7 - 2.11 Å
Structure data

PDB-3o4k:
Crystal structure of the complex of peptidoglycan recognition protein (PGRP-S) and lipoteichoic acid at 2.1 A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

PDB-3rt4:
Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-LTC:
(2S)-1-({3-O-[2-(acetylamino)-4-amino-2,4,6-trideoxy-beta-D-galactopyranosyl]-alpha-D-glucopyranosyl}oxy)-3-(heptanoyloxy)propan-2-yl (7Z)-pentadec-7-enoate

ChemComp-GOL:
GLYCEROL

ChemComp-TLA:
L(+)-TARTARIC ACID

ChemComp-HOH:
WATER

ChemComp-LP5:
(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE

Source
  • camelus dromedarius (Arabian camel)
KeywordsIMMUNE SYSTEM / Immune response / secreted / antimicrobial / PGRP / Antibiotic / Peptidoglycan Binding

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