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-Structure paper
Title | Optimization of the interligand overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 132, Page 4544-4545, Year 2010 |
Publish date | Jan 14, 2010 (structure data deposition date) |
![]() | Sledz, P. / Silvestre, H.L. / Hung, A.W. / Ciulli, A. / Blundell, T.L. / Abell, C. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | ![]() PDB-3le8: |
Chemicals | ![]() ChemComp-2B5: ![]() ChemComp-EDO: ![]() ChemComp-GOL: ![]() ChemComp-EOH: ![]() ChemComp-HOH: |
Source |
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![]() | LIGASE / Fragment-based drug discovery / ILOE / fragment linking / ATP-binding / Cytoplasm / Magnesium / Metal-binding / Nucleotide-binding / Pantothenate biosynthesis |