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Title | Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors |
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Journal, issue, pages | J. Med. Chem., Vol. 53, Page 419-431, Year 2010 |
Publish date | Nov 30, 2009 (structure data deposition date) |
Authors | Kamenecka, T. / Jiang, R. / Song, X. / Duckett, D. / Chen, W. / Ling, Y.Y. / Habel, J. / Laughlin, J.D. / Chambers, J. / Figuera-Losada, M. ...Kamenecka, T. / Jiang, R. / Song, X. / Duckett, D. / Chen, W. / Ling, Y.Y. / Habel, J. / Laughlin, J.D. / Chambers, J. / Figuera-Losada, M. / Cameron, M.D. / Lin, L. / Ruiz, C.H. / Lograsso, P.V. |
External links | J. Med. Chem. / PubMed:19947601 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-3kvx: |
Chemicals | ChemComp-FMY: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / JNK3 / MAPK10 / inhibitor / ATP-binding / Epilepsy / Kinase / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase |