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-Structure paper
Title | Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone. |
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Journal, issue, pages | J. Med. Chem., Vol. 53, Page 499-503, Year 2010 |
Publish date | Oct 15, 2009 (structure data deposition date) |
![]() | Kung, P.P. / Huang, B. / Zhang, G. / Zhou, J.Z. / Wang, J. / Digits, J.A. / Skaptason, J. / Yamazaki, S. / Neul, D. / Zientek, M. ...Kung, P.P. / Huang, B. / Zhang, G. / Zhou, J.Z. / Wang, J. / Digits, J.A. / Skaptason, J. / Yamazaki, S. / Neul, D. / Zientek, M. / Elleraas, J. / Mehta, P. / Yin, M.J. / Hickey, M.J. / Gajiwala, K.S. / Rodgers, C. / Davies, J.F. / Gehring, M.R. |
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Methods | X-ray diffraction |
Resolution | 1.95 - 2.4 Å |
Structure data | ![]() PDB-3k97: ![]() PDB-3k98: ![]() PDB-3k99: |
Chemicals | ![]() ChemComp-4CD: ![]() ChemComp-DMS: ![]() ChemComp-HOH: ![]() ChemComp-1RC: ![]() ChemComp-PO4: ![]() ChemComp-PFT: |
Source |
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![]() | CHAPERONE / HSP90 / ATP binding domain / N-terminal domain / inhibition / Acetylation / Alternative splicing / ATP-binding / Cytoplasm / Nucleotide-binding / Phosphoprotein / Stress response |