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-Structure paper
Title | Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 1680-1684, Year 2010 |
Publish date | Aug 28, 2009 (structure data deposition date) |
Authors | Wurz, R.P. / Pettus, L.H. / Henkle, B. / Sherman, L. / Plant, M. / Miner, K. / McBride, H.J. / Wong, L.M. / Saris, C.J. / Lee, M.R. ...Wurz, R.P. / Pettus, L.H. / Henkle, B. / Sherman, L. / Plant, M. / Miner, K. / McBride, H.J. / Wong, L.M. / Saris, C.J. / Lee, M.R. / Chmait, S. / Mohr, C. / Hsieh, F. / Tasker, A.S. |
External links | Bioorg. Med. Chem. Lett. / PubMed:20138761 |
Methods | X-ray diffraction |
Resolution | 2.25 Å |
Structure data | PDB-3itz: |
Chemicals | ChemComp-P66: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Serine/Threonine-Protein Kinase / Alternative splicing / ATP-binding / Cytoplasm / Kinase / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism |