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-Structure paper
Title | Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 5119-5123, Year 2009 |
Publish date | Jun 25, 2009 (structure data deposition date) |
Authors | Su, D.S. / Lim, J.J. / Tinney, E. / Wan, B.L. / Young, M.B. / Anderson, K.D. / Rudd, D. / Munshi, V. / Bahnck, C. / Felock, P.J. ...Su, D.S. / Lim, J.J. / Tinney, E. / Wan, B.L. / Young, M.B. / Anderson, K.D. / Rudd, D. / Munshi, V. / Bahnck, C. / Felock, P.J. / Lu, M. / Lai, M.T. / Touch, S. / Moyer, G. / Distefano, D.J. / Flynn, J.A. / Liang, Y. / Sanchez, R. / Prasad, S. / Yan, Y. / Perlow-Poehnelt, R. / Torrent, M. / Miller, M. / Vacca, J.P. / Williams, T.M. / Anthony, N.J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19631528 |
Methods | X-ray diffraction |
Resolution | 2.7 - 2.98 Å |
Structure data | PDB-3i0r: PDB-3i0s: |
Chemicals | ChemComp-RT3: ChemComp-RT7: |
Source |
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Keywords | TRANSFERASE / HIV-1 reverse transcriptase / non-nucleoside inhibition / nucleotidyltrasferase / AIDS / Aspartyl protease / Capsid maturation / Capsid protein / Cell membrane / Cytoplasm / DNA integration / DNA recombination / DNA-directed DNA polymerase / Endonuclease / Host-virus interaction / Hydrolase / Lipoprotein / Magnesium / Membrane / Metal-binding / Multifunctional enzyme / Myristate / Nuclease / Nucleotidyltransferase / Nucleus / Phosphoprotein / Protease / Ribosomal frameshifting / RNA-binding / RNA-directed DNA polymerase / Viral nucleoprotein / Virion / Zinc / Zinc-finger |