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-Structure paper
Title | Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 4088-4091, Year 2009 |
Publish date | May 7, 2009 (structure data deposition date) |
Authors | Owen, D.R. / Walker, J.K. / Jon Jacobsen, E. / Freskos, J.N. / Hughes, R.O. / Brown, D.L. / Bell, A.S. / Brown, D.G. / Phillips, C. / Mischke, B.V. ...Owen, D.R. / Walker, J.K. / Jon Jacobsen, E. / Freskos, J.N. / Hughes, R.O. / Brown, D.L. / Bell, A.S. / Brown, D.G. / Phillips, C. / Mischke, B.V. / Molyneaux, J.M. / Fobian, Y.M. / Heasley, S.E. / Moon, J.B. / Stallings, W.C. / Joseph Rogier, D. / Fox, D.N. / Palmer, M.J. / Ringer, T. / Rodriquez-Lens, M. / Cubbage, J.W. / Blevis-Bal, R.M. / Benson, A.G. / Acker, B.A. / Maddux, T.M. / Tollefson, M.B. / Bond, B.R. / Macinnes, A. / Yu, Y. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19540112 |
Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | PDB-3hdz: |
Chemicals | ChemComp-PD6: ChemComp-ZN: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / PDE5 / PDE-5 / inhibition / Alternative splicing / cAMP / Phosphoprotein / Polymorphism Allosteric enzyme / cGMP / cGMP-binding / Magnesium / Metal-binding / Nucleotide-binding / Zinc |