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-Structure paper
Title | Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 5420-5428, Year 2009 |
Publish date | Mar 23, 2009 (structure data deposition date) |
Authors | Groll, M. / McArthur, K.A. / Macherla, V.R. / Manam, R.R. / Potts, B.C. |
External links | J. Med. Chem. / PubMed:19678642 |
Methods | X-ray diffraction |
Resolution | 2.41 - 2.5 Å |
Structure data | PDB-3gpt: PDB-3gpw: PDB-3hye: |
Chemicals | ChemComp-GPT: ChemComp-HOH: ChemComp-SA1: ChemComp-HYE: |
Source |
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Keywords | HYDROLASE / proteasome / ubiquitin / cancer therapy / inhibitor / immunology / time dependent leaving group elimination / Cytoplasm / Nucleus / Phosphoprotein / Protease / Threonine protease / Isopeptide bond / Ubl conjugation / Zymogen / time-dependent elimination of a defined leaving group |