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-Structure paper
Title | Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin |
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Journal, issue, pages | J. Mol. Biol., Vol. 391, Page 552-564, Year 2009 |
Publish date | Nov 6, 2007 (structure data deposition date) |
Authors | Baum, B. / Muley, L. / Heine, A. / Smolinski, M. / Hangauer, D. / Klebe, G. |
External links | J. Mol. Biol. / PubMed:19520086 |
Methods | X-ray diffraction |
Resolution | 1.58 - 2.25 Å |
Structure data | PDB-2zc9: PDB-2zda: PDB-2zfp: PDB-2zgx: PDB-2zo3: PDB-3dhk: PDB-3dux: PDB-3f68: |
Chemicals | ChemComp-NA: ChemComp-22U: ChemComp-HOH: ChemComp-PO4: ChemComp-32U: ChemComp-19U: ChemComp-29U: ChemComp-33U: ChemComp-23U: ChemComp-64U: ChemComp-91U: |
Source |
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Keywords | BLOOD CLOTTING/HYDROLASE INHIBITOR / Blood Clotting/Serine Protease Inhibitors / Secreted / Sulfation / Acute phase / Blood coagulation / Cleavage on pair of basic residues / Disease mutation / Gamma-carboxyglutamic acid / Glycoprotein / Hydrolase / Kringle / Zymogen / BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX / Blood Clotting/Hydrolase Inhibitors / Protease / Serine protease / Hydrolase/Hydrolase Inhibitor / Blood Clotting / Hydrolase Inhibitor / Protease inhibitor / Serine protease inhibitor / Hydrolase-Hydrolase Inhibitor complex |