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-Structure paper
Title | Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity |
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Journal, issue, pages | Proc. Natl. Acad. Sci. Usa, Vol. 105, Page 3041-3046, Year 2008 |
Publish date | Jan 29, 2008 (structure data deposition date) |
Authors | Tsai, J. / Lee, J.T. / Wang, W. / Zhang, J. / Cho, H. / Mamo, S. / Bremer, R. / Gillette, S. / Kong, J. / Haass, N.K. ...Tsai, J. / Lee, J.T. / Wang, W. / Zhang, J. / Cho, H. / Mamo, S. / Bremer, R. / Gillette, S. / Kong, J. / Haass, N.K. / Sproesser, K. / Li, L. / Smalley, K.S. / Fong, D. / Zhu, Y.L. / Marimuthu, A. / Nguyen, H. / Lam, B. / Liu, J. / Cheung, I. / Rice, J. / Suzuki, Y. / Luu, C. / Settachatgul, C. / Shellooe, R. / Cantwell, J. / Kim, S.H. / Schlessinger, J. / Zhang, K.Y. / West, B.L. / Powell, B. / Habets, G. / Zhang, C. / Ibrahim, P.N. / Hirth, P. / Artis, D.R. / Herlyn, M. / Bollag, G. |
External links | Proc. Natl. Acad. Sci. Usa / PubMed:18287029 |
Methods | X-ray diffraction |
Resolution | 1.98 - 2.65 Å |
Structure data | PDB-3c4c: PDB-3c4e: PDB-3c4f: PDB-4fk3: |
Chemicals | ChemComp-324: ChemComp-HOH: ChemComp-IMD: ChemComp-C4E: ChemComp-C4F: ChemComp-325: |
Source |
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Keywords | TRANSFERASE / B-RAF / BRAF / RAF / PROTO-ONCOGENE / SERINE/THREONINE KINASE / ATP-binding / Cardiomyopathy / Cytoplasm / Disease mutation / Metal-binding / Nucleotide-binding / Phorbol-ester binding / Phosphoprotein / Polymorphism / Serine/threonine-protein kinase / Zinc / Zinc-finger / PIM-1 / Alternative initiation / Manganese / Membrane / Nucleus / FIBROBLAST GROWTH FACTOR RECEPTOR / TYROSINE KINASE DOMAIN / RECEPTOR TYROSINE KINASE / FGFR1 / FGFR / Alternative splicing / Chromosomal rearrangement / Dwarfism / Glycoprotein / Heparin-binding / Immunoglobulin domain / Kallmann syndrome / Transmembrane / Tyrosine-protein kinase / Transferase/Transferase inhibitor / oncogenic V600E / Kinase-Kinase inhibitor complex / Transferase-Transferase inhibitor complex |