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-Structure paper
Title | Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. |
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Journal, issue, pages | Mol. Pharmacol., Vol. 73, Page 104-110, Year 2008 |
Publish date | Oct 19, 2007 (structure data deposition date) |
Authors | Wang, H. / Ye, M. / Robinson, H. / Francis, S.H. / Ke, H. |
External links | Mol. Pharmacol. / PubMed:17959709 |
Methods | X-ray diffraction |
Resolution | 2.07 Å |
Structure data | PDB-3b2r: |
Chemicals | ChemComp-VDN: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / cGMP phosphodiesterase; PDE5-inhibitor potency; vardenafil; sildenafil; LevitraTM. / Allosteric enzyme / Alternative splicing / cGMP-binding / Magnesium / Metal-binding / Nucleotide-binding / Phosphorylation / Polymorphism / Zinc |