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Structure paper

TitleThe oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
Journal, issue, pagesEMBO Rep., Vol. 12, Page 463-469, Year 2011
Publish dateMar 8, 2011 (structure data deposition date)
AuthorsChowdhury, R. / Yeoh, K.K. / Tian, Y.M. / Hillringhaus, L. / Bagg, E.A. / Rose, N.R. / Leung, I.K. / Li, X.S. / Woon, E.C. / Yang, M. ...Chowdhury, R. / Yeoh, K.K. / Tian, Y.M. / Hillringhaus, L. / Bagg, E.A. / Rose, N.R. / Leung, I.K. / Li, X.S. / Woon, E.C. / Yang, M. / McDonough, M.A. / King, O.N. / Clifton, I.J. / Klose, R.J. / Claridge, T.D. / Ratcliffe, P.J. / Schofield, C.J. / Kawamura, A.
External linksEMBO Rep. / PubMed:21460794
MethodsX-ray diffraction
Resolution2.02 - 2.4 Å
Structure data

PDB-2ybk:
JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-2ybp:
JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

PDB-2ybs:
JMJD2A COMPLEXED WITH S-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

PDB-2yc0:
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-2yde:
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH S-2-HYDROXYGLUTARATE
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-2HG:
(2R)-2-hydroxypentanedioic acid

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-S2G:
(2S)-2-HYDROXYPENTANEDIOIC ACID

ChemComp-FE2:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-FE:
Unknown entry

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / NON-HEME / IRON / 2-OXOGLUTARATE / DIOXYGENASE / OXYGENASE / DOUBLE-STRANDED BETA HELIX / DSBH / FACIAL TRIAD / METAL BINDING PROTEIN / EPIGENETIC AND TRANSCRIPTION REGULATION / CHROMATIN REGULATOR / HYDROXYLATION / OXIDOREDUCTASE/PEPTIDE / OXIDOREDUCTASE-PEPTIDE COMPLEX / NON-HEME IRON / METAL-BINDING / TRANSCRIPTION / HELIX-LOOP-HELIX-BETA / ASPARAGINYL/ASPARTYL HYDROXYLASE / TRANSCRIPTION AND EPIGENETIC REGULATION / SIGNALING / DEVELOPMENT / CELL STRUCTURE / ANKYRIN REPEAT DOMAIN / ARD / BETA-HYDROXYLATION / TRANSCRIPTION ACTIVATOR/INHIBITOR / PHOSPHORYLATION / S-NITROSYLATION / ASPARAGINYL/ ASPARTYL HYDROXYLASE

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