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TitleDiscovery of Selective Aminothiazole Aurora Kinase Inhibitors
Journal, issue, pagesAcs Chem. Biol., Vol. 3, Page 180-, Year 2008
Publish dateNov 15, 2007 (structure data deposition date)
AuthorsAndersen, C.B. / Wan, Y. / Chang, J.W. / Riggs, B. / Lee, C. / Liu, Y. / Sessa, F. / Villa, F. / Kwiatkowski, N. / Suzuki, M. ...Andersen, C.B. / Wan, Y. / Chang, J.W. / Riggs, B. / Lee, C. / Liu, Y. / Sessa, F. / Villa, F. / Kwiatkowski, N. / Suzuki, M. / Nallan, L. / Heald, R. / Musacchio, A. / Gray, N.S.
External linksAcs Chem. Biol. / PubMed:18307303
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-2vgp:
Crystal structure of Aurora B kinase in complex with a aminothiazole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-AD6:
4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide

ChemComp-HOH:
WATER

Source
  • xenopus laevis (African clawed frog)
KeywordsTRANSFERASE / NUCLEOTIDE-BINDING / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / COILED COIL / CELL DIVISION / KINASE / CANCER / INCENP / NUCLEUS / MITOSIS / AURORA B / METAL-BINDING / AMINOTHIAZOLE / PHOSPHORYLATION / MAGNESIUM / CELL CYCLE / CENTROMERE / MICROTUBULE

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