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TitleSulfolobus Solfataricus DNA Polymerase Dpo4 is Partially Inhibited by "Wobble" Pairing between O6- Methylguanine and Cytosine, But Accurate Bypass is Preferred.
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 1456-, Year 2007
Publish dateOct 4, 2006 (structure data deposition date)
AuthorsEoff, R.L. / Irimia, A. / Egli, M. / Guengerich, F.P.
External linksJ. Biol. Chem. / PubMed:17105728
MethodsX-ray diffraction
Resolution2.5 - 2.6 Å
Structure data

PDB-2j6s:
Ternary complex of Sulfolobus solfataricus Dpo4 DNA polymerase, O6- methylguanine modified DNA, and dATP.
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2j6t:
Ternary complex of Sulfolobus solfataricus Dpo4 DNA polymerase, O6- methylguanine modified DNA, and dATP.
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2j6u:
Ternary complex of Sulfolobus solfataricus Dpo4 DNA polymerase, O6- methylguanine modified DNA, and dGTP.
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DGT:
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

Source
  • sulfolobus solfataricus (archaea)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / TRANSFERASE-DNA COMPLEX / MUTATOR PROTEIN / DNA REPLICATION / O6-METHYLGUANINE / TRANSFERASE / METAL-BINDING / DNA POLYMERASE / TRANSLESION DNA SYNTHESIS / DNA-DIRECTED DNA POLYMERASE / DPO4 / MAGNESIUM / DNA REPAIR / DNA DAMAGE / DNA-BINDING / NUCLEOTIDYLTRANSFERASE / SULFOLOBUS SOLFATARICUS

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