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TitleBlockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
Journal, issue, pagesNAT. MED. (N. Y. ), Vol. 11, Page 936-943, Year 2005
Publish dateJun 30, 2005 (structure data deposition date)
AuthorsCamps, M. / Ruckle, T. / Ji, H. / Ardissone, V. / Rintelen, F. / Shaw, J. / Ferrandi, C. / Chabert, C. / Gillieron, C. / Francon, B. ...Camps, M. / Ruckle, T. / Ji, H. / Ardissone, V. / Rintelen, F. / Shaw, J. / Ferrandi, C. / Chabert, C. / Gillieron, C. / Francon, B. / Martin, T. / Gretener, D. / Perrin, D. / Leroy, D. / Vitte, P.-A. / Hirsch, E. / Wymann, M.P. / Cirillo, R. / Schwarz, M.K. / Rommel, C.
External linksNAT. MED. (N. Y. ) / PubMed:16127437
MethodsX-ray diffraction
Resolution2.7 - 2.9 Å
Structure data

PDB-2a4z:
Crystal Structure of human PI3Kgamma complexed with AS604850
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-2a5u:
Crystal Structure of human PI3Kgamma complexed with AS605240
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-BYM:
(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE

ChemComp-HOH:
WATER

ChemComp-QYT:
(5E)-5-(QUINOXALIN-6-YLMETHYLENE)-1,3-THIAZOLIDINE-2,4-DIONE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Protein-inhibitor complex / PI3Kg

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