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Title | (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes |
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Journal, issue, pages | J. Med. Chem., Vol. 48, Page 141-151, Year 2005 |
Publish date | Aug 12, 2004 (structure data deposition date) |
Authors | Kim, D. / Wang, L. / Beconi, M. / Eiermann, G.J. / Fisher, M.H. / He, H. / Hickey, G.J. / Kowalchick, J.E. / Leiting, B. / Lyons, K. ...Kim, D. / Wang, L. / Beconi, M. / Eiermann, G.J. / Fisher, M.H. / He, H. / Hickey, G.J. / Kowalchick, J.E. / Leiting, B. / Lyons, K. / Marsilio, F. / McCann, M.E. / Patel, R.A. / Petrov, A. / Scapin, G. / Patel, S.B. / Roy, R.S. / Wu, J.K. / Wyvratt, M.J. / Zhang, B.B. / Zhu, L. / Thornberry, N.A. / Weber, A.E. |
External links | J. Med. Chem. / PubMed:15634008 |
Methods | X-ray diffraction |
Resolution | 2.1 Å |
Structure data | PDB-1x70: |
Chemicals | ChemComp-NAG: ChemComp-NA: ChemComp-715: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / ALPHA/BETA / BETA-PROPELLER / DIMER |