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Structure paper

TitleStructure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Journal, issue, pagesNature, Vol. 425, Page 98-102, Year 2003
Publish dateMay 6, 2003 (structure data deposition date)
AuthorsSung, B.-J. / Hwang, K.Y. / Jeon, Y.H. / Lee, J.I. / Heo, Y.-S. / Kim, J.H. / Moon, J. / Yoon, J.M. / Hyun, Y.-L. / Kim, E. ...Sung, B.-J. / Hwang, K.Y. / Jeon, Y.H. / Lee, J.I. / Heo, Y.-S. / Kim, J.H. / Moon, J. / Yoon, J.M. / Hyun, Y.-L. / Kim, E. / Eum, S.J. / Park, S.-Y. / Lee, J.-O. / Lee, T.G. / Ro, S. / Cho, J.M.
External linksNature / PubMed:12955149
MethodsX-ray diffraction
Resolution2.3 - 2.83 Å
Structure data

PDB-1udt:
Crystal structure of Human Phosphodiesterase 5 complexed with Sildenafil(Viagra)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1udu:
Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)
Method: X-RAY DIFFRACTION / Resolution: 2.83 Å

PDB-1uho:
Crystal structure of Human Phosphodiesterase 5 complexed with Vardenafil(Levitra)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-VIA:
5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE / medication*YM

ChemComp-HOH:
WATER

ChemComp-CIA:
6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE / medication*YM

ChemComp-VDN:
2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE / medication, inhibitor*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / cGMP-specific phosphodiesterase 5 / sildenafil / selective inhibitor / Tadalafil / PDE5 inhibitor complex

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