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-Structure paper
Title | Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis |
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Journal, issue, pages | J. Med. Chem., Vol. 48, Page 4803-4814, Year 2005 |
Publish date | Jun 9, 2004 (structure data deposition date) |
![]() | Ioanoviciu, A. / Antony, S. / Pommier, Y. / Staker, B.L. / Stewart, L. / Cushman, M. |
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Methods | X-ray diffraction |
Resolution | 3.1 Å |
Structure data | ![]() PDB-1tl8: |
Chemicals | ![]() ChemComp-AI3: |
Source |
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![]() | ISOMERASE/DNA / COMPLEX (ISOMERASE-DNA) / DNA / TOPOISOMERASE I / DRUG / POISON / IDENOISOQUINOLINE / ISOMERASE-DNA complex |