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-Structure paper
Title | Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis |
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Journal, issue, pages | BIOORG. MED. CHEM. LETT., Vol. 14, Page 3727-3731, Year 2004 |
Publish date | Apr 30, 2004 (structure data deposition date) |
![]() | Lu, T. / Markotan, T. / Coppo, F. / Tomczuk, B. / Crysler, C. / Eisennagel, S. / Spurlino, J. / Gremminger, L. / Soll, R.M. / Giardino, E.C. / Bone, R. |
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Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | ![]() PDB-1t4u: ![]() PDB-1t4v: |
Chemicals | ![]() ChemComp-81A: ![]() ChemComp-HOH: ![]() ChemComp-14A: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |