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Structure paper

TitleStructural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
Journal, issue, pagesNature, Vol. 426, Page 525-530, Year 2003
Publish dateOct 27, 2003 (structure data deposition date)
AuthorsRenault, L. / Guibert, B. / Cherfils, J.
External linksNature / PubMed:14654833
MethodsX-ray diffraction
Resolution1.46 - 1.86 Å
Structure data

PDB-1r8m:
SEC7 DOMAIN OF THE ARF EXCHANGE FACTOR ARNO WITH BREFELDIN A-SENSITIZING MUTATIONS
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-1r8q:
FULL-LENGTH ARF1-GDP-MG IN COMPLEX WITH BREFELDIN A AND A SEC7 DOMAIN
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

PDB-1r8s:
ARF1[DELTA1-17]-GDP IN COMPLEX WITH A SEC7 DOMAIN CARRYING THE MUTATION OF THE CATALYTIC GLUTAMATE TO LYSINE
Method: X-RAY DIFFRACTION / Resolution: 1.46 Å

PDB-1s9d:
ARF1[DELTA 1-17]-GDP-MG IN COMPLEX WITH BREFELDIN A AND A SEC7 DOMAIN
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-G3D:
GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE

ChemComp-AFB:
1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE / antivirus*YM

ChemComp-ZN:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-SO4:
SULFATE ION

ChemComp-SO3:
SULFITE ION

Source
  • homo sapiens (human)
  • bos taurus (cattle)
KeywordsExchange Factor / PROTEIN TRANSPORT/EXCHANGE FACTOR / PROTEIN TRANSPORT-EXCHANGE FACTOR complex

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