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-Structure paper
Title | Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop. |
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Journal, issue, pages | Structure, Vol. 11, Page 399-410, Year 2003 |
Publish date | Jun 30, 2003 (structure data deposition date) |
Authors | Wu, S.Y. / McNae, I. / Kontopidis, G. / McClue, S.J. / McInnes, C. / Stewart, K.J. / Wang, S. / Zheleva, D.I. / Marriage, H. / Lane, D.P. ...Wu, S.Y. / McNae, I. / Kontopidis, G. / McClue, S.J. / McInnes, C. / Stewart, K.J. / Wang, S. / Zheleva, D.I. / Marriage, H. / Lane, D.P. / Taylor, P. / Fischer, P.M. / Walkinshaw, M.D. |
External links | Structure / PubMed:12679018 |
Methods | X-ray diffraction |
Resolution | 1.95 - 2.8 Å |
Structure data | PDB-1pw2: PDB-1pxi: PDB-1pxj: PDB-1pxk: PDB-1pxl: |
Chemicals | ChemComp-HOH: ChemComp-CK1: ChemComp-CK2: ChemComp-CK3: ChemComp-CK4: |
Source |
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Keywords | TRANSFERASE / PROTEIN KINASE / CELL CYCLE / PHOSPHORYLATION / CELL DIVISION / MITOSIS / INHIBITION / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / 3D-STRUCTURE. |