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-Structure paper
Title | Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors |
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Journal, issue, pages | PROTEINS, Vol. 55, Page 805-813, Year 2004 |
Publish date | Jul 2, 2003 (structure data deposition date) |
Authors | El-Kabbani, O. / Darmanin, C. / Schneider, T.R. / Hazemann, I. / Ruiz, F. / Oka, M. / Joachimiak, A. / Schulze-Briese, C. / Tomizaki, T. / Mitschler, A. / Podjarny, A. |
External links | PROTEINS / PubMed:15146479 |
Methods | X-ray diffraction |
Resolution | 0.92 - 1.1 Å |
Structure data | PDB-1pwl: PDB-1pwm: |
Chemicals | ChemComp-BFI: ChemComp-NAP: ChemComp-HOH: ChemComp-CL: ChemComp-FID: |
Source |
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Keywords | OXIDOREDUCTASE / ALDOSE REDUCTASE / ATOMIC RESOLUTION / TERNARY COMPLEX / INHIBITOR BINDING |