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-Structure paper
Title | Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug |
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Journal, issue, pages | Biochemistry, Vol. 40, Page 1897-1902, Year 2001 |
Publish date | Jan 8, 2001 (structure data deposition date) |
![]() | Phan, J. / Koli, S. / Minor, W. / Dunlap, R.B. / Berger, S.H. / Lebioda, L. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | ![]() PDB-1hvy: |
Chemicals | ![]() ChemComp-D16: ![]() ChemComp-UMP: ![]() ChemComp-BME: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / Tomudex / Raltitrexed |