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TitleStructural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein.
Journal, issue, pagesJ Infect Dis, Vol. 219, Issue 3, Page 415-419, Year 2019
Publish dateJan 9, 2019
AuthorsJacob C Milligan / Diptiben V Parekh / Katherine M Fuller / Manabu Igarashi / Ayato Takada / Erica Ollmann Saphire /
PubMed AbstractEbola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, although they are ...Ebola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, although they are ineffective against other members of the Ebolavirus genus that also cause periodic, lethal outbreaks. In this study, we present a crystal structure of a pan-ebolavirus antibody, 6D6, as well as single-particle electron microscopy reconstructions of 6D6 in complex with Ebola and Bundibugyo virus glycoproteins. 6D6 binds to the conserved glycoprotein fusion peptide, implicating it as a site of immune vulnerability that could be exploited to reliably elicit a pan-ebolavirus neutralizing antibody response.
External linksJ Infect Dis / PubMed:30203042 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution1.96 - 20.0 Å
Structure data

EMDB-9048:
Ebola virus glycoprotein in complex with antigen binding fragment of chimeric mouse IgG 6D6
Method: EM (single particle) / Resolution: 20.0 Å

EMDB-9049:
Bundibugyo virus glycoprotein in complex with antigen binding fragment of chimeric mouse IgG 6D6
Method: EM (single particle) / Resolution: 20.0 Å

PDB-6dg2:
Antigen Binding Fragment of the Pan-ebolavirus Monoclonal Antibody 6D6
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • Ebola virus - Mayinga, Zaire, 1976
  • mus musculus (house mouse)
  • Bundibugyo virus
KeywordsIMMUNE SYSTEM / Antibody / Monoclonal / Antigen Binding Fragment / Fab / Ebola

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