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TitleSARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes.
Journal, issue, pagesCell Rep Med, Vol. 4, Issue 11, Page 101267, Year 2023
Publish dateNov 21, 2023
AuthorsSteven C Wall / Naveenchandra Suryadevara / Changil Kim / Andrea R Shiakolas / Clinton M Holt / Emma B Irbe / Perry T Wasdin / Yukthi P Suresh / Elad Binshtein / Elaine C Chen / Seth J Zost / Elizabeth Canfield / James E Crowe / Mary Ann Thompson-Arildsen / Daniel J Sheward / Robert H Carnahan / Ivelin S Georgiev /
PubMed AbstractFrom the beginning of the COVID-19 pandemic, children have exhibited different susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, reinfection, and disease ...From the beginning of the COVID-19 pandemic, children have exhibited different susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, reinfection, and disease compared with adults. Motivated by the established significance of SARS-CoV-2-neutralizing antibodies in adults, here we characterize SARS-CoV-2-specific antibody repertoires in a young cohort of individuals aged from 5 months to 18 years old. Our results show that neutralizing antibodies in children possess similar genetic features compared to antibodies identified in adults, with multiple antibodies from children belonging to previously established public antibody clonotypes in adults. Notably, antibodies from children show potent neutralization of circulating SARS-CoV-2 variants that have cumulatively resulted in resistance to virtually all approved monoclonal antibody therapeutics. Our results show that children can rely on similar SARS-CoV-2 antibody neutralization mechanisms compared to adults and are an underutilized source for the discovery of effective antibody therapeutics to counteract the ever-evolving pandemic.
External linksCell Rep Med / PubMed:37935199 / PubMed Central
MethodsEM (single particle)
Resolution17.0 - 19.0 Å
Structure data

EMDB-41075: SARS-CoV-2 spike in complex with Fab 71281-33
Method: EM (single particle) / Resolution: 17.0 Å

EMDB-41076: SARS-CoV-2 spike in complex with Fab 71281-33 (2)
Method: EM (single particle) / Resolution: 19.0 Å

Source
  • Severe acute respiratory syndrome coronavirus 2
  • Homo sapiens (human)

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