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-Structure paper
Title | Cryo-EM structures of NLRP3 reveal its self-activation mechanism |
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Journal, issue, pages | Nat Commun, Year 2024 |
Publish date | May 18, 2023 (structure data deposition date) |
Authors | Yu X / Matico RE / Miller R / Schoubroeck BV / Grauwen K / Suarez J / Pietrak B / Haloi N / Yin Y / Tresadern GJ ...Yu X / Matico RE / Miller R / Schoubroeck BV / Grauwen K / Suarez J / Pietrak B / Haloi N / Yin Y / Tresadern GJ / Perez-Benito L / Lindahl E / Bottelbergs A / Oehlrich D / Opdenbosch NV / Sharma S |
External links | Search PubMed |
Methods | EM (single particle) |
Resolution | 3.39 - 4.32 Å |
Structure data | EMDB-40811, PDB-8swf: EMDB-40820, PDB-8swk: EMDB-40855, PDB-8sxn: |
Chemicals | ChemComp-7YN: ChemComp-ATP: |
Source |
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Keywords | IMMUNE SYSTEM / Activated NLRP3 / Cryo-EM / Closed NLRP3 / NLRP3 NEK7 complex |