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Title | Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. |
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Journal, issue, pages | Cell Host Microbe, Vol. 30, Issue 11, Page 1527-11539.e5, Year 2022 |
Publish date | Nov 9, 2022 |
Authors | Yunlong Cao / Weiliang Song / Lei Wang / Pan Liu / Can Yue / Fanchong Jian / Yuanling Yu / Ayijiang Yisimayi / Peng Wang / Yao Wang / Qianhui Zhu / Jie Deng / Wangjun Fu / Lingling Yu / Na Zhang / Jing Wang / Tianhe Xiao / Ran An / Jing Wang / Lu Liu / Sijie Yang / Xiao Niu / Qingqing Gu / Fei Shao / Xiaohua Hao / Bo Meng / Ravindra Kumar Gupta / Ronghua Jin / Youchun Wang / Xiaoliang Sunney Xie / Xiangxi Wang / |
PubMed Abstract | Recently emerged SARS-CoV-2 Omicron subvariant, BA.2.75, displayed a growth advantage over circulating BA.2.38, BA.2.76, and BA.5 in India. However, the underlying mechanisms for enhanced ...Recently emerged SARS-CoV-2 Omicron subvariant, BA.2.75, displayed a growth advantage over circulating BA.2.38, BA.2.76, and BA.5 in India. However, the underlying mechanisms for enhanced infectivity, especially compared with BA.5, remain unclear. Here, we show that BA.2.75 exhibits substantially higher affinity for host receptor angiotensin-converting enzyme 2 (ACE2) than BA.5 and other variants. Structural analyses of BA.2.75 spike shows its decreased thermostability and increased frequency of the receptor binding domain (RBD) in the "up" conformation under acidic conditions, suggesting enhanced low-pH-endosomal cell entry. Relative to BA.4/BA.5, BA.2.75 exhibits reduced evasion of humoral immunity from BA.1/BA.2 breakthrough-infection convalescent plasma but greater evasion of Delta breakthrough-infection convalescent plasma. BA.5 breakthrough-infection plasma also exhibits weaker neutralization against BA.2.75 than BA.5, mainly due to BA.2.75's distinct neutralizing antibody (NAb) escape pattern. Antibody therapeutics Evusheld and Bebtelovimab remain effective against BA.2.75. These results suggest BA.2.75 may prevail after BA.4/BA.5, and its increased receptor-binding capability could support further immune-evasive mutations. |
External links | Cell Host Microbe / PubMed:36270286 / PubMed Central |
Methods | EM (single particle) |
Resolution | 3.19 - 3.98 Å |
Structure data | EMDB-34034, PDB-7yqt: EMDB-34035, PDB-7yqu: EMDB-34036, PDB-7yqv: EMDB-34037, PDB-7yqw: EMDB-34038, PDB-7yqx: EMDB-34039, PDB-7yqy: EMDB-34040, PDB-7yqz: EMDB-34041, PDB-7yr0: EMDB-34042, PDB-7yr1: EMDB-34043, PDB-7yr2: EMDB-34044, PDB-7yr3: |
Chemicals | ChemComp-NAG: ChemComp-ZN: ChemComp-CL: ChemComp-HOH: |
Source |
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Keywords | VIRAL PROTEIN / spike / STRUCTURAL PROTEIN / SARS-CoV-2 / BA.2.75 / pH5.5 / S309 / VIRALPROTEIN |